Schizophrenia get most ; the great unwashed often associate the disease with a loose conglomeration of symptoms such as hearing representative and hallucinations . Even the word schizophrenia is misleading — it approximately translates to the splitting of the mind . Researchers have been skin to understand the disease , which only affects 1 percent of the U.S. population , but is one of the most debilitating genial illnesses .
Three new bailiwick in the journalNaturehave record that a few little changes in our genome can cause this disorder and many people in the population carry the anomalies .
The generator scanned the genome of 2,663 people with schizophrenic disorder and 13,498 without it , looking for individual nucleotide polymorphism ( SNP ) . SNP are genetic mutation present in most people , but more unremarkably found in people with schizophrenic psychosis . The researchers find that people with schizophrenic psychosis had many deviations on their genes in the Major Histocompatibility Complex ( MHC ) , a clump of genes responsible for ascertain immune reactions .
Researchers say this uncovering is especially intriguing because many people in the general population deal the same variation on their MHC genes , but not everyone develop schizophrenia . They even speculate that if a mother becomes ill while pregnant , this can cause the genes to mutate from a normal to abnormal factor .
The researchers also regain variation on NRGN and TCF4 , which affects some of the pathway that hold brain development , memory , and knowledge . " It ’s a disease of mentation and emotions , the two role of the brain that define us as a species and define us as individuals,“ said Kari Stefansson , chief operating officer of the Icelandic company deCODE Genetics and one of the investigator .
